The Effect of Vitamin D Administration on Androgen Levels in Addition to Metformin Treatment in Adolescent Girls with Hyperandrogenism

Abstract

This retrospective study was planned to examine the relationship between glucose metabolism, androgen and lipid profiles after vitamin D and metformin treatments in adolescent girls with hyperandrogenism. Forty-five adolescent female patients diagnosed with hyperandrogenism were divided into three groups. The first group of patients was given metformin (M), the second group was given metformin and vitamin D drops (MdD), and the third group were those who received oral metformin and vitamin D ampoules (MsD). Biochemical and hormonal parameters at the end of 8 weeks were compared statistically. The vitamin D level was higher in the metformin-vitamin D stoss treated group than metformin-vitamin D drops. There was a positive correlation between vitamin D and SHBG in the metformin group (r =0.65, p<0.01). A significant correlation was observed between triglyceride and insulin in both groups given vitamin D, and there was a decrease in these two values (p<0.05). There was a positive correlation between total testosterone and Alanine transaminase (ALT) in the MsD group (p<0.05). Additionally, a positive correlation was observed between SHBG and HDL-cholesterol in three groups. There was a significant correlation between androgen and lipid parameters in the 8-week metformin and vitamin D treated groups. Long-term studies using high-dose vitamin D are needed to support our results.