TY - JOUR AU - Yılmaz, Ayşegül AU - Soylu Üstünkoyuncu, Pembe AU - Dursun, Ismail AU - Gunduz, Zubeyde PY - 2022/08/30 Y2 - 2024/03/29 TI - Evaluation of The Renal Function in The Intrauterine Growth Restricted Rats and The Effect of Maternal Glucocorticoids JF - The Journal of Pediatric Academy JA - JPA VL - 3 IS - 2 SE - Original Article DO - 10.51271/jpea-2022-155 UR - https://jpediatricacademy.com/index.php/jpa/article/view/155 SP - 54-59 AB - <p>The purpose of the study was to determine the effect of maternal glucocorticoids on experimental growth retarded<br />rats and the effect of maternal undernutrition in different gestation periods for function of the kidney. This study<br />had two sections. In the first section, 5 groups were formed. 10g/d diet was given in the 1st, 2nd, and 3rd trimester<br />and throughout the pregnancy period. The control group was fed a normal diet. In the second section, 3 groups<br />formed and all the rats take 10 g/d diet throughout pregnancy period. To determine the effect of endogenous<br />glucocorticoids first group was treated with metyrapone, second group metyrapone+dexamethasone and the<br />placebo injected saline until 14 days of pregnancy. The offsprings body and kidney weights were detected in<br />the 0, 3rd and 20th weeks of age. Renal extraction functions and blood pressures from tail detected in the 20th<br />week of age. Urinary excretion and glomerular filtration rate were low in rats that had dietary restriction in the<br />last trimester. The glomerular filtration rates were found to be low in the group that had diet restriction during<br />the whole pregnancy. Blood pressure values were found to be lower in the group that had diet restriction during<br />their pregnancy compared to the control group. Kidney weights were similar in all groups in the first phase. It<br />was observed that renal excretion functions were preserved in the group receiving metyrapone treatment, but<br />there was no statistically significant difference between the results. Low blood pressures were normalized with<br />metyrapone treatment. The kidney sizes at the 20th week of the rats which receiving metyrapone treatment were<br />found to be smaller than those receiving physiological saline solution. Food restriction destroys renal functions<br />but no effects with high blood pressure in adulthood. Glucocortiod exposure in pregnancy may reduce renal<br />development.</p> ER -