Can Mean Platelet Volume be an Inflammatory Marker in Pediatric Diabetic Ketoacidosis? Inflammatory Markers in Pediatric Diabetic Ketoacidosis

Gül Trabzon; Dilek Çiçek; Şükrü Güngör; Şeyma  Demiray Güllü; Esra Yazarlı; Ufuk Utku Güllü; Çiğdem El

doi:10.4274/jpea.2024.352

Authors

Gül Trabzon Hatay Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Department of Pediatric Endocrinology, Hatay, Türkiye https://orcid.org/0000-0002-9262-5678
Dilek Çiçek Mersin City Hospital, Clinic of Pediatric Endocrinology, Mersin, Türkiye https://orcid.org/0000-0001-5652-1401
Şükrü Güngör İnönü University Faculty of Medicine, Department of Pediatric Gastroenterology, Malatya, Türkiye https://orcid.org/0000-0002-0433-5970
Şeyma Demiray Güllü Hatay Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Department of Pediatrics, Hatay, Türkiye https://orcid.org/0000-0003-3596-2704
Esra Yazarlı Hatay Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Department of Pediatrics, Hatay, Türkiye https://orcid.org/0000-0002-2347-8168
Ufuk Utku Güllü Hatay Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Department of Pediatric Cardiology, Hatay, Türkiye https://orcid.org/0000-0002-5561-3598
Çiğdem El Hatay Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Department of Pediatrics, Hatay, Türkiye https://orcid.org/0000-0002-7110-3504

DOI:

https://doi.org/10.4274/jpea.2024.352

Keywords:

mean platelet volume, diabetic ketoacidosis, diabetes mellitus

Abstract

This study explores the association between mean platelet volume (MPV) and other hematological parameters in children with diabetic ketoacidosis (DKA), aiming to identify hematological changes and their implications for management and treatment strategies in pediatric type 1 diabetes mellitus (T1DM). In a retrospective, two-center analysis of 323 children, participants were categorized into three groups: DKA, T1DM without ketoacidosis, and healthy controls (95). Hematological parameters and HbA1c levels were collected. Blood pH levels classified DKA severity, and statistical analyses included One-way ANOVA, correlation tests, receiver operating characteristic curve analysis, and logistic regression to assess the predictive value of hematological parameters for DKA. No significant demographic differences were noted among the groups. Patients with DKA exhibited significantly lower MPV and higher neutrophil-to-lymphocyte ratio (NLR) compared with both patients with T1DM without ketoacidosis and healthy controls. Logistic regression showed MPV ≤9.35 and NLR ≥2.73 significantly increased DKA risk. This study demonstrated a significant relationship between DKA and altered hematological parameters (MPV and NLR) in pediatric patients, highlighting their potential as markers for early detection and risk assessment of DKA.