Assesment of Damage in Juvenile Idiopathic Arthritis: Single Center Experience


Abstract views: 213

Authors

  • Sevda Asadova
  • Ayşenur Paç Kısaarslan Corresponding Author
  • Sümeyra Özdemir Çiçek
  • Nihal Şahin
  • Sema Nur Taşkın
  • Şeyda Doğantan
  • Muammer Hakan Poyrazoğlu

DOI:

https://doi.org/10.51271/jpea-2022-169

Keywords:

Juvenile, arthritis, factors, damage

Abstract

Introduction:It is essential to evaluate the activation and the articular and extra-articular damage during the Juvenile Idiopathic Arthritis(JIA) disease course.

Objectives:This study aimed to evaluate the damage status and affecting factors in JIA patients.

Methods:Juvenile Arthritis Damage Index articular(JADI-A) and extra-articular(E) were evaluated in 204 JIA patients who had been followed up for two years andmore. JADI-A and E affecting factors were assessed by univariate and multivariate logistic regression analysis.

Results: In this study,127(62.6%) of the patients were female. The median age was 13(IQR: 11-16), and the age at diagnosis was 7(IQR: 4-10) years. The median follow-up time was 5(IQR: 4-8) years. Ninety-two(45.3%) patients had comorbid diseases. JADI-A were median:0(min-max: 0-24), JADI-E were median:0(min-max:0-4).The annual attacks number [OR:1,759 (CI:1,300-2,379],p:<0,001),annual eritrocyte sedimantation rate (ESR) [OR:1,072(CI:1,021-1,125),p:0.005] were effective on JADI-A scores. The CRP at the first admission [OR:1.007(CI: 1,000-1,014), p:0.037], the annual ESR[OR:1,051(CI:1,008-1,095),p:0.019] were found to be effective on the JADI-E. The ideal cut-off point of the  attacks number and ESR affecting JADI-A scores were 1.38[AUC:0.734(0.641-0.828),p:0.001] and 14.32[AUC:0.617(0.514-0.721),p:0.027], respectively. The ideal cut-off point of the CRP and ESR affecting JADI-E scores were 13,25[AUC:0,662(0,541-0,782),p:0,009],and15,10[AUC:0.674(0.567-0.780),p:0.002], respectively. Steroid related complications such as, obesity in 12 (5.9%), hirsutism in 3 (1.5%), transient adrenal suppression in 14 (6.9%), 8 (3.9%), and osteoporosis were detectedin 7 (3.4%) patients.

Conclusion: We have shown that parameters used routinely can be helpful to predict damage. We also think that new criteria should be added to the scoring.

Author Biographies

Sevda Asadova

Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

Ayşenur Paç Kısaarslan , Corresponding Author

Division of Pediatric Rheumatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

Sümeyra Özdemir Çiçek

Division of Pediatric Rheumatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

Nihal Şahin

Division of Pediatric Rheumatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

Sema Nur Taşkın

Division of Pediatric Rheumatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

Şeyda Doğantan

Division of Pediatric Rheumatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

Muammer Hakan Poyrazoğlu

Division of Pediatric Rheumatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

The ideal cut-off points affected JADI-A and E scores

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Published

2022-12-23

How to Cite

Asadova, S. ., Kısaarslan , A. P. ., Özdemir Çiçek , S., Şahin, N. ., Taşkın, . S. N. ., Doğantan, . Şeyda ., & Poyrazoğlu, M. H. . (2022). Assesment of Damage in Juvenile Idiopathic Arthritis: Single Center Experience. The Journal of Pediatric Academy, 3(3), 95–103. https://doi.org/10.51271/jpea-2022-169

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